Prescription Required
Quantity:84
Price:$39.99$6.16 per unit
Country:Canada
Manufacturer:BGP Pharma
Please Select... 84 from Canada Capsules $39.99
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Baclofen is a muscle relaxant used to treat muscle spasms caused by conditions such as multiple sclerosis, spinal cord injuries, or cerebral palsy. It works by improving the function and quality of the muscles.
Baclofen may also be used to treat other conditions, such as cerebral palsy and spasticity, which is a physical condition that can cause weakness, muscle stiffness, or painful movement. It is a common treatment for such conditions.
Baclofen is used to treat muscle spasms caused by conditions such as multiple sclerosis, spinal cord injuries, or cerebral palsy. It can also be used to treat other conditions.
Baclofen can be taken with or without food. It is usually taken for as long as 6 to 8 weeks to see results. The duration of treatment may depend on the condition being treated and the severity of the muscle spasms.
Baclofen works by inhibiting the muscle spasmolytic activity of the skeletal muscle cells in the spinal cord. It helps to relax the muscles and improve the function of the muscles.
The most common side effects of baclofen may be:
The following side effects may also be experienced by some people:
Background:Baclofen (B) is a centrally acting drug that is effective in the management of multiple sclerosis and other spinal cord diseases. Baclofen is a competitively substituted enantiomer of [4H-1-(2,2'-biphenyl)propanoic acid]. Baclofen is rapidly converted to its isomer of the isomeric form of the racemic enantiomer, which has a rapid and reproducible pharmacokinetic and pharmacodynamic profile. Baclofen is rapidly absorbed in humans and has been shown to have a wide range of pharmacokinetic properties. The pharmacokinetic properties of the racemic enantiomers of B were determined in vitro by using bromide salt and their pharmacokinetic and pharmacodynamic parameters after oral administration in dogs and rabbits. Baclofen is rapidly absorbed from human milk, and its bioavailability is increased after the administration of high doses. The bioavailability of bromide is also increased in dogs. The pharmacokinetic properties of bromide are similar to those of the enantiomers of the racemic enantiomers of Bac. The pharmacokinetic parameters for the racemic enantiomers of Bac are not affected by bromide and can be used to estimate the relative bioavailability of Bac from humans.
Clinical Pharmacology:The pharmacokinetic parameters of bromide were evaluated in 10 normal volunteers and in 11 patients with spinal cord diseases. In the 10 patients with spinal cord diseases, bromide pharmacokinetic and pharmacodynamic parameters were determined by a single-dose of oral bromide. In healthy volunteers, bromide pharmacokinetics were well correlated with a wide range of pharmacokinetic parameters including body weight, mean protein binding, and mean apparent clearance (CL/F). The mean apparent clearance (CL/F) of bromide in normal volunteers was approximately 5-10 times that of normal volunteers. In the 10 patients with spinal cord diseases, bromide pharmacokinetics were not affected by the administration of high doses of bromide (greater than 100 mg). The mean CL/F of bromide in normal volunteers was approximately 10 and the mean apparent clearance (CL/F) was approximately 50 to 100 ml/min. The mean steady-state volume of distribution (Vss) and apparent volume of distribution (Vd) of bromide were approximately 100 and 25 L/kg, respectively. The mean steady-state Vss of bromide in healthy volunteers were approximately 8 and approximately 30 L/kg, respectively. The mean apparent volume of distribution (Vd) of bromide in normal volunteers was approximately 3 L/kg. The mean apparent clearance (CL/F) of bromide in healthy volunteers was approximately 4 and the CL/F of bromide in normal volunteers was approximately 5. The mean apparent volume of distribution (Vss) of bromide in patients with spinal cord diseases was approximately 5 L/kg and the Vss of bromide in patients with spinal cord diseases was approximately 6 L/kg. The mean apparent volume of distribution (Vd) of bromide in patients with spinal cord diseases was approximately 2 L/kg and the Vd of bromide in patients with spinal cord diseases was approximately 1 L/kg. The mean apparent clearance (CL/F) of bromide in patients with spinal cord diseases was approximately 1 and the CL/F of bromide in patients with spinal cord diseases was approximately 2. The mean apparent volume of distribution (Vss) of bromide in patients with spinal cord diseases was approximately 2 L/kg and the Vss of bromide in patients with spinal cord diseases was approximately 4 L/kg.
Conclusion:The pharmacokinetic properties of bromide are similar to that of the enantiomers of the racemic enantiomers of Bac. The pharmacokinetic parameters of bromide were well correlated with a wide range of pharmacokinetic parameters including body weight, mean protein binding, and mean apparent clearance (CL/F). The mean apparent clearance of bromide in normal volunteers was approximately 5-10 times that of normal volunteers. The mean apparent clearance of bromide in patients with spinal cord diseases was approximately 1 and the Vss of bromide in patients with spinal cord diseases was approximately 4 L/kg.
[Generic Equivalent of Baclofen]
Prescription Required
Quantity:1
Price:$59.99$9.29 per unit
Country:Canada
Please Select... 1 from Canada Tablet $59.99
* The product images are for reference only. Generic equivalents may also be supplied by alternate manufacturers.
Baclofen is used for the treatment of muscle spasms caused due to cerebral palsy, multiple sclerosis, stroke, and others. It is a derivative of gliclazide, a GABA agonist, and is a GABA analogue. Baclofen is known to produce muscle pain and weakness. Baclofen is used in the treatment of the following conditions:
Baclofen is available as an oral tablet, a chewable oral capsule, and a liquid suspension (as a liquid). It is available in the dosage form of tablets, chewable tablets, and liquid suspensions.